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Mouse DKK3 ELISA Kit

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Principle Of The Test
Solid Phase Sandwich ELISA
Intended Use
For the quantitative determination of Mouse DKK3 concentration in serum.
The use of this kit for other sample types need be validated by the end user due to the complexity of natural targets and unpredictable interference.
Assay Range
18.75-1200 pg/mL
Sensitivity
The minimum detectable dose of Mouse DKK3 is typically less than 7.95 pg/mL. The MDD was determined by adding three standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
Materials Provided
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
Storage
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA
Images
Mouse DKK3 ELISA Kit, TYPICAL DATA
[Click to enlarge image]
Caption:
This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Background

DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.

References
  • Yue W, et al., 2008. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis, 29 (1): 84-92.
  • Ding Z, et al., 2009. Promoter methylation and mRNA expression of DKK3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol, 15 (21):2595-601.
  • Size / Price
    Catalog:KIT50247-1
    List Price: $470.00  (Save $0.00)
    Price:$470.00      [How to order]
    Availabilityon Sale
    Images
    • Mouse DKK3 ELISA Kit, TYPICAL DATA
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