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Human CEACAM6 / CD66c ELISA Kit

DatasheetComponentsSpecific ReferencesReviewsRelated Products
Principle Of The Test
Solid Phase Sandwich ELISA
Intended Use
For the quantitative determination of Human CEACAM6 / CD66c concentration in serum.
The use of this kit for other sample types need be validated by the end user due to the complexity of natural targets and unpredictable interference.
Assay Range
15.63-1000 pg/mL
Sensitivity
The minimum detectable dose of Human CEACAM6 / CD66c is typically less than 7.95 pg/mL. The MDD was determined by adding three standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
Materials Provided
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
Storage
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA
Human CEACAM6 ELISA Kit Standard Curve
[Click to enlarge image]
Caption:
This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Human CEACAM6 / CD66c ELISA Kit, TYPICAL DATA
Human CEACAM6 ELISA Kit Specificity
[Click to enlarge image]
Caption:
This assay recognizes both recombinant and natural Human CEACAM6. The factors listed above were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.

Human CEACAM6 / CD66c ELISA Kit, SPECIFICITY
CEACAM6/CD66c Background

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.

Human CEACAM6/CD66c References
  • Duxbury MS, et al. (2004) Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 23(34): 5834-42.
  • Lewis-Wambi JS, et al. (2008) Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 44(12): 1770-9.
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    Catalog: KIT10823-1
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    • Human CEACAM6 / CD66c ELISA Kit, TYPICAL DATA
    • Human CEACAM6 / CD66c ELISA Kit, SPECIFICITY
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"