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Human BBOX1 / Gamma-BBH Protein (His & GST Tag)

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Human BBOX1 Protein Product Information
Synonym:BBOX1, BBH, BBOX
Protein Construction:A DNA sequence encoding the human BBOX1 (O75936) (Met1-Asn387) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Expressed Host:Baculovirus-Insect Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human BBOX1 Protein QC Testing
Purity:> 85 % as determined by SDS-PAGE
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human BBOX1 /GST chimera consists of 624 amino acids and has a calculated molecular mass of 72.5 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human BBOX1 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human BBOX1 Protein SDS-PAGE
Human BBOX1 / Gamma-BBH Protein (His & GST Tag) SDS-PAGE
Other BBOX1 Recombinant Protein Products
BBOX1 / Gamma-BBH Background

BBOX1, also known as gamma-BBH, belongs to the gamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treat angina andmyocardial infarction. Mildronate may also be beneficial for the treatment ofneurological disorder, diabetes, and seizures and alcohol intoxication.

Human BBOX1 / Gamma-BBH References
  • Vaz FM. et al., 1998, Biochem Biophys Res Commun. 250 (2): 506-10.
  • Paul HS. et al., 1992, Eur J Biochem. 203 (3): 599-605.
  • Dawany NB. et al., 2011, Int J Cancer. 128 (12): 2881-91.
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    Catalog: 15675-H20B-100
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