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FABP4 / ALBP / A-FABP Antibody, Rabbit MAb

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FABP4Antibody Product Information
Immunogen:Recombinant Human FABP4 / ALBP / A-FABP protein (Catalog#12109-H07E)
Clone ID:001
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human FABP4 / ALBP / A-FABP (rh FABP4 / ALBP / A-FABP; Catalog#12109-H07E; P15090; Cys2-Ala132,29Ala/Thr).
FABP4Antibody Usage Guide
Specificity:Human FABP4 / ALBP / A-FABP
Has cross-reactivity in ELISA with
Mouse FABP3
No cross-reactivity in ELISA with
Human FABP6
Application:IHC-P

IHC-P: 0.5-5 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Images
FABP4 / ALBP / A-FABP Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human FABP4 in human appendix with rabbit monoclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
FABP4 / ALBP / A-FABP Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human FABP4 in human lung cancer with rabbit monoclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
Background

Mouse fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

References
  • van Dongen,M.J. et al., 2002, J Am Chem Soc. 124 (40): 11874-80.
  • Coll, B. et al., 2008, Atherosclerosis  199 (1):147-53.
  • Hoashi,S. et al., 2008, BMC Genet. 9 :84.
  • Cai,H. et al., 2010, Bioorg Med Chem Lett  20 (12):3675-9.
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    Catalog:12109-R001-100
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    • FABP4 / ALBP / A-FABP Antibody, Rabbit MAb, Immunohistochemistry
    • FABP4 / ALBP / A-FABP Antibody, Rabbit MAb, Immunohistochemistry
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