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TROP-2 / TACSTD2 Antibody, Rabbit MAb

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TACSTD2Antibody Product Information
Immunogen:Recombinant Mouse TROP-2 / TACSTD2 protein (Catalog#50922-M08H)
Clone ID:046
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TROP-2 / TACSTD2 (rM TROP-2 / TACSTD2; Catalog#50922-M08H; Q8BGV3; Met1-Gln270).
TACSTD2Antibody Usage Guide
Specificity:Mouse TROP-2 / TACSTD2
Has cross-reactivity in ELISA with
Human TROP2
Application:IHC-P

IHC-P: 0.05-2 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Images
TROP-2 / TACSTD2 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse TACSTD2 in mouse kidney with rabbit monoclonal antibody (0.05 µg/mL, formalin-fixed paraffin embedded sections).
TROP-2 / TACSTD2 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse TACSTD2 in mouse skin with rabbit monoclonal antibody (0.05 µg/mL, formalin-fixed paraffin embedded sections).
Background

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

References
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
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    Catalog:50922-R046-100
    List Price: $290.00  (Save $0.00)
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    • TROP-2 / TACSTD2 Antibody, Rabbit MAb, Immunohistochemistry
    • TROP-2 / TACSTD2 Antibody, Rabbit MAb, Immunohistochemistry
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