|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Canine BCA-1 / CXCL13 protein (Catalog#70057-D07E)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Canine BCA-1 / CXCL13 (rh BCA-1 / CXCL13; Catalog#70057-D07E; XP_851619.3; Val23-Asn110). BCA-1 / CXCL13 specific IgG was purified by Canine BCA-1 / CXCL13 affinity chromatography.|
|Canine BCA-1 / CXCL13|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Canine BCA-1 / CXCL13. The detection limit for Canine BCA-1 / CXCL13 is < 0.039 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).