|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Human NKG2D / CD314 protein (Catalog#10575-H07B)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Human NKG2D / CD314 (rh NKG2D / CD314; Catalog#10575-H07B; NKG2D_HUMAN; Phe78-Val216). NKG2D / CD314 specific IgG was purified by Human NKG2D / CD314 affinity chromatography.|
|Human NKG2D / CD314|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human NKG2D / CD314. The detection limit for Human NKG2D / CD314 is < 0.039 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
NKG2D, also known as CD314, is an immune receptor which consists of two disulphide-linked type II transmembrane proteins with short intracellular proteins uncapable to transduce signals. In order to transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.