|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Human Cbl-c / CBL-3 protein (Catalog#15659-H20B)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Human Cbl-c / CBL-3 (rh Cbl-c / CBL-3; Catalog#15659-H20B; AAH28915.1; Met1-Ala474). Cbl-c / CBL-3 specific IgG was purified by Human Cbl-c / CBL-3 affinity chromatography.|
|Human Cbl-c / CBL-3|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Cbl-c / CBL-3. The detection limit for Human Cbl-c / CBL-3 is < 0.039 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c gene.