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Cbl-c / CBL-3 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human CBLC Antibody Product Information
Immunogen:Recombinant Human Cbl-c / CBL-3 protein (Catalog#15659-H20B)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human Cbl-c / CBL-3 (rh Cbl-c / CBL-3; Catalog#15659-H20B; AAH28915.1; Met1-Ala474). Cbl-c / CBL-3 specific IgG was purified by Human Cbl-c / CBL-3 affinity chromatography.
Human CBLC Antibody Usage Guide
Specificity:Human Cbl-c / CBL-3
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Cbl-c / CBL-3. The detection limit for Human Cbl-c / CBL-3 is < 0.039 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other CBLC Antibody Products
Cbl-c / CBL-3 Background

CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c gene.

Human Cbl-c / CBL-3 References
  • Kim M. et al., 1999, Gene. 239 (1): 145-54.
  • Courbard JR. et al., 2003, J. Biol. Chem. 277 (47): 45267-75.
  • Keane MM. et al., 1999, Oncogene. 18 (22): 3365-75.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"