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BACE2 / Beta secretase 2 Antibody, Rabbit PAb, Antigen Affinity Purified

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Mouse BACE2 Antibody Product Information
Immunogen:Recombinant Mouse BACE2 / Beta secretase 2 protein (Catalog#51031-M08H)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Mouse BACE2 / Beta secretase 2 (rh BACE2 / Beta secretase 2; Catalog#51031-M08H; Q9JL18; Met1-Pro462). BACE2 / Beta secretase 2 specific IgG was purified by Mouse BACE2 / Beta secretase 2 affinity chromatography.
Mouse BACE2 Antibody Usage Guide
Specificity:Mouse BACE2 / Beta secretase 2

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse BACE2 / Beta secretase 2. The detection limit for Mouse BACE2 / Beta secretase 2 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other BACE2 Antibody Products
BACE2 / Beta secretase 2 Background

BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

Mouse BACE2 / Beta secretase 2 References
  • Hussain I, et al. (2001) Prodomain processing of Asp1 (BACE2) is autocatalytic. J Biol Chem. 276(26):23322-8.
  • Solans A, et al. (2000) A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. Cytogenet Cell Genet. 89(3-4): 177-84.
  • Hussain I, et al. (2001) ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci. 16(5):609-19.
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