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|Recombinant Rat EGFR / HER1 / ErbB1 protein (Catalog#80100-R08H)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Rat EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#80100-R08H; E7CXR8; Met1-Ser646). EGFR / HER1 / ErbB1 specific IgG was purified by Rat EGFR / HER1 / ErbB1 affinity chromatography.|
|Rat EGFR / HER1 / ErbB1|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat EGFR / HER1 / ErbB1. The detection limit for Rat EGFR / HER1 / ErbB1 is 0.00245 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.