|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Rat LTBR / TNFRSF3 protein (Catalog#80178-R08H)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Rat LTBR / TNFRSF3 (rh LTBR / TNFRSF3; Catalog#80178-R08H; NP_001008316.1; Met1-Ala218). LTBR / TNFRSF3 specific IgG was purified by Rat LTBR / TNFRSF3 affinity chromatography.|
|Rat LTBR / TNFRSF3|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat LTBR / TNFRSF3. The detection limit for Rat LTBR / TNFRSF3 is 0.00975 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.