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Defensin / Beta-defensin 3 / DEFB103 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human DEFB103A Antibody Product Information
Immunogen:Recombinant Human Defensin / Beta-defensin 3 / DEFB103 protein (Catalog#10849-H07E)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human Defensin / Beta-defensin 3 / DEFB103 (rh Defensin / Beta-defensin 3 / DEFB103 ; Catalog#10849-H07E; P81534; Gly23-Lys6). Defensin / Beta-defensin 3 / DEFB103 specific IgG was purified by Human Defensin / Beta-defensin 3 / DEFB103 affinity chromatography.
Human DEFB103A Antibody Usage Guide
Specificity:Human Defensin / Beta-defensin 3 / DEFB103

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Defensin / Beta-defensin 3 / DEFB103 . The detection limit for Human Defensin / Beta-defensin 3 / DEFB103 is 0.039 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other DEFB103A Antibody Products
Defensin / Beta-defensin 3 / DEFB103  Background

Beta-defensin 3 is a member of the defensin family. Defensin family is comprised by microbicidal and cytotoxic peptides made by neutrophils. Members of the beta-defensin 3 family are highly similar in protein sequence. Beta-defensin 3 shows antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Beta-defensin 3 is abundantly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. It is also expressed in salivary gland, bone marrow, colon, stomach, polyp and larynx. However, in small intestine, it cannot be detected. Defensin has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. Beta-defensin 3 kills multiresistant S.aureus and vancomycin-resistent E.faecium. It has no significant hemolytic activity.

Human Defensin / Beta-defensin 3 / DEFB103  References
  • Garca JR, et al. (2002) Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res. 306(2):257-64.
  • Dunsche A, et al. (2002) The novel human beta-defensin-3 is widely expressed in oral tissues. Eur J Oral Sci. 110(2):121-4.
  • Abiko Y, et al. (2004) Upregulated expression of human beta defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b. J Dermatol Sci. 31(3): 225-8.
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