|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Human IL36B / IL1F8 protein (Catalog#10579-HNAE)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Human IL36B / IL1F8 (rh IL36B; Catalog#10579-HNAE; Q9NZH7-2; Met1-Glu157). Total IgG was purified by Protein A affinity chromatography.|
|Human IL36B / IL1F8|
ELISA: 0.5-1.0 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human IL36B / IL1F8. The detection limit for Human IL36B / IL1F8 is <0.039 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.|
Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.