|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Cynomolgus IL6 / IL-6 protein (Catalog#90197-CNAE)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Cynomolgus IL6 / IL-6 (rh IL6; Catalog#90197-CNAE; NP_001036198.2; Pro29-Met212). Total IgG was purified by Protein A affinity chromatography.|
|Cynomolgus IL6 / IL-6|
ELISA: 0.5-1.0 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Cynomolgus IL6 / IL-6. The detection limit for Cynomolgus IL6 / IL-6 is <0.039 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.|
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.