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FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit MAb

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Human FDPS Antibody Product Information
Immunogen:Recombinant Human FDPS / Farnesyl Diphosphate Synthase protein (Catalog#13229-H07E)
Clone ID:005
Ig Type:Rabbit IgG
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human FDPS / Farnesyl Diphosphate Synthase (rh FDPS / Farnesyl Diphosphate Synthase; Catalog#13229-H07E; NP_001129294.1; Met1-Lys353).
Human FDPS Antibody Usage Guide
Specificity:Human FDPS / Farnesyl Diphosphate Synthase
Application:WB, ELISA, ICC/IF, IF, FCM, IP

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human FDPS / Farnesyl Diphosphate Synthase. The detection limit for Human FDPS / Farnesyl Diphosphate Synthase is 0.0012 ng/well.

FCM: 0.5-2 μg/Test

ICC/IF: 10-25 μg/mL

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human FDPS Antibody WB Application Image
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit MAb, Western blot
Human FDPS Antibody IF Application Image
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Immunofluorescence staining of Human FDPS in HUVEC cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human FDPS monoclonal antibody (15 µg/ml) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit MAb, Immunofluorescence
Human FDPS Antibody FC Application Image
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Flow cytometric analysis of Human FDPS expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human FDPS, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit MAb
Human FDPS Antibody IP Application Image
FDPS / Farnesyl Diphosphate Synthase Antibody, Rabbit MAb, Immunoprecipitation
Other FDPS Antibody Products
FDPS / Farnesyl Diphosphate Synthase Background

Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.

Human FDPS / Farnesyl Diphosphate Synthase References
  • Pjetursson BE, et al. (2007) Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs). Clin Oral Implants Res. 3:97-113.
  • Eschbach S, et al. (2009) Clinical evaluation of all-ceramic posterior three-unit FDPs made of In-Ceram Zirconia. Int J Prosthodont. 22(5):490-2.
  • Moshage HJ, et al. (1990) Differential effects of endotoxin and fibrinogen degradation products (FDPS) on liver synthesis of fibrinogen and albumin: evidence for the involvement of a novel monokine in the stimulation of fibrinogen synthesis induced by FDPS. Int J Biochem. 22(12): 1393-400.
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