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Human PMVK / phosphomevalonate kinase Protein (His Tag)

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Human PMKI/PMVK Protein Product Information
Synonym:PMVK, PMKI
Protein Construction:A DNA sequence encoding the mature form of human PMVK(Q15126) (Met1-Leu192) was expressed with a polyhistidine tag at the N-terminus.
Species:Human
Expressed Host:E. coli
Shipping:Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Human PMKI/PMVK Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Bio-Activity:Kinase activity untested
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:His
Molecule Mass:The recombinant human PMVK consists of 207 amino acids and predicts a molecular mass of 23.8 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 50mM MOPS, 150mM KCl, 1mM DTT, pH 7.0.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human PMKI/PMVK Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human PMKI/PMVK Protein SDS-PAGE
Human PMVK / phosphomevalonate kinase Protein (His Tag) SDS-PAGE
Other PMKI/PMVK Recombinant Protein Products
14583-H07E
PMVK / phosphomevalonate kinase Background

PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.

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Catalog: 14583-H07E-50
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"