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Human CIRBP / Cold-inducible RNA-binding Protein (His Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Human CIRBP Protein Product Information
Synonym:CIRBP, A18HNRNP, CIRP
Protein Construction:A DNA sequence encoding the human CIRBP (Q14011) (Met1-Glu172) was expressed with a polyhistide tag at the N-terminus.
Species:Human
Expressed Host:E. coli
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human CIRBP Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:His
Molecule Mass:The recombinant human CIRBP consists of 187 amino acids and predicts a molecular mass of 20.5 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, 0.25M Imi, 20% glycerol.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human CIRBP Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human CIRBP Protein SDS-PAGE
Human CIRBP / Cold-inducible RNA-binding Protein (His Tag) SDS-PAGE
Other CIRBP Recombinant Protein Products
14578-H07E
CIRBP / Cold-inducible RNA-binding Protein Background

CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator.CIRBP can bind the 3 translated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.

Human CIRBP / Cold-inducible RNA-binding Protein References
  • Artero-Castro A. et al., 2009, Mol Cell Biol. 29 (7): 1855-68.
  • Zeng Y. et al., 2009, J Cell Biochem. 107 (1): 179-88.
  • Brochu C. et al., 2013, PLoS One. 8 (2): e57426.
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    Catalog: 14578-H07E-20
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"