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Human PPC-DC / PPCDC Protein (His Tag)

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Human PPCDC Protein Product Information
Synonym:PPCDC, COAC
Protein Construction:A DNA sequence encoding the mature form of human PPCDC (AAH14409.1) (Met1-Ser204) was expressed with a polyhistidine tag at the N-terminus.
Species:Human
Expressed Host:E. coli
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human PPCDC Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:His
Molecule Mass:The recombinant human PPCDC consists of 219 amino acids and predicts a molecular mass of 24.3 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, 15% Glycerol, pH 8.0.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human PPCDC Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human PPCDC Protein SDS-PAGE
Human PPC-DC / PPCDC Protein (His Tag) SDS-PAGE
Other PPCDC Recombinant Protein Products
14572-H07E
PPC-DC / PPCDC Background

PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. This process include several steps: the phosphorylation of pantothenate, the conversion of 4’-hosphopantothenate to 4''-phosphopantetheine, the adenylation by phosphopantetheine adenylyltransferase to form dephospho-CoA and the phosphorylation by dephospho-CoA kinase to form CoA. PPC-DC, one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine.

Human PPC-DC / PPCDC References
  • Zody MC. et al., 2006, Nature. 440: 671-5.
  • Ota T. et al., 2004, Nat Genet. 36: 40-5.
  • Clark HF. et al., 2003, Genome Res. 13: 2265-70.
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    Catalog: 14572-H07E-20
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"