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Human KLHL2 Protein (GST Tag)

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KLHL2Protein Product Information
Synonym:KLHL2
Protein Construction:A DNA sequence encoding the mature form of human KLHL2 (AAH36468.1) (Met1-Pro306) was fused with the GST tag at the N-terminus.
Species:Human
Expressed Host:E. coli
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
KLHL2Protein QC Testing
Purity:> 85 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human KLHL2 /GST chimera consists of 540 amino acids and has a predicted molecular mass of 62.2 kDa. It migrates as an approximately 63 KDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
KLHL2Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
14556-H09E
Background

KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is predominantly expressed in brain. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin binding and protein binding. KLHL2 localizes in various compartments such as actin cytoskeleton, cytoplasm, membrane and nucleus. It may also plays a role in organizing the actin cytoskeleton of the brain cells.

References
  • Minx P, et al. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 434:724-31.
  • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36:40-5.
  • Jiang S, et al. (1999) Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 10:2361-75.
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