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Human LILRB2 / ILT4 / LIR-2 Protein (Fc Tag)

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Human LILRB2/ILT4 Protein Product Information
Synonym:LILRB2, ILT4, LIR2, MIR10
Protein Construction:A DNA sequence encoding the human LILRB2 (AAH36827.1) (Met1-Val461) was expressed with the Fc region of human IgG1 at the C-terminus.
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human LILRB2/ILT4 Protein QC Testing
Purity:> 85 % as determined by SDS-PAGE
Bio-Activity:Measured by its ability to support the adhesion of HSB2 human peripheral blood acute lymphoblastic leukemia cells.
When 8 x 10E4 cells/well are added to LILRB2 coated plates (4.4 μg/mL with 100 μL/well), approximately >45% cells will adhere for 1 hour incubation at 37℃.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Gln 22
Molecule Mass:The recombinant human LILRB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 681 amino acids and has a predicted molecular mass of 74.8 kDa. The apparent molecular mass of the protein is approximately 93 kDa in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human LILRB2/ILT4 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human LILRB2/ILT4 Protein SDS-PAGE
Human LILRB2 / ILT4 / LIR-2 Protein (Fc Tag) SDS-PAGE
Human LILRB2 / ILT4 / LIR-2 Protein (Fc Tag) SDS-PAGE
Other LILRB2/ILT4 Recombinant Protein Products
LILRB2 / ILT4 / LIR-2 Background

ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

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Catalog: 14132-H02H-50
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