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Coagulation Factor VIII / FVIII / F8 Antibody (Heavy Chain), Rabbit MAb

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Human F8 Antibody Product Information
Immunogen:Recombinant Human Coagulation Factor VIII / FVIII / F8 protein
Clone ID:226
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor VIII / FVIII / F8 protein.
Human F8 Antibody Usage Guide
Specificity:Human Coagulation Factor VIII / FVIII / F8 Heavy Chain

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human FⅧ. The detection limit for Human FⅧ is approximately 0.078ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other F8 Antibody Products
Coagulation Factor VIII / FVIII / F8 Background

Coagulation Factor VIII, also known as FVIII and F8, is a member of the multicopper oxidase family. Coagulation Factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. It contains 3 F5/8 type A domains, 2 F5/8 type C domains and 6 plastocyanin-like domains. FVIII is synthesized in the liver, and perhaps in other tissues. It is a coagulation cofactor which circulates bound to von Willebrand factor and is part of the intrinsic coagulation pathway. It is a macromolecular complex composed of two separate entities, one of which, when deficient, results in hemophilia A, and the other, when deficient, results in von Willebrand's disease. Hemophilia A is a disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery.

Human Coagulation Factor VIII / FVIII / F8 References
  • Toole JJ. et al., 1984, Nature. 312(5992): 342-7.
  • Truett MA. et al., 1985, DNA. 4(5): 333-49.
  • Antonarakis SE. et al., 1995, Haemost. 74(1): 322-8.
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