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Human NRG1-alpha Protein (EGF Domain, Fc Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
NRG1Protein Product Information
Synonym:ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, NDF, SMDF
Protein Construction:A DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) EGF-like domain (Ser 177-Lys 241) was fused with the Fc region of human IgG1 at the N-terminus.
Species:Human
Expressed Host:Human Cells
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
NRG1Protein QC Testing
Purity:> 97 % as determined by SDS-PAGE
Bio-Activity:1. Measured by its ability to biotinylated Human ErbB4-Fc (cat:10363-H03H) in functional Elisa.
2. Measured by its ability to biotinylated Rhesus ErbB3 (Cat:90043-K02H) in functional Elisa.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Glu
Molecule Mass:The recombinant human NRG1(177-241)/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 326 amino acids and has a calculated molecular mass of 35.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 38 kDa.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
NRG1Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
13499-H01H
Background

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 

References
  • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
  • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
  • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
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    Catalog:13499-H01H-50
    List Price: $178.00  (Save $0.00)
    Price:$178.00      [How to order]
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    • Human NRG1-alpha Protein (EGF Domain, Fc Tag) SDS-PAGE
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