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Human SUSD4 / Sushi domain-containing Protein 4 Protein (Fc Tag)

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Human SUSD4 Protein Product Information
Protein Construction:A DNA sequence encoding the human SUSD4 (Q5VX71-3) (Met1-Phe290) was fused with Fc region of mouse IgG at the C-terminus.
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human SUSD4 Protein QC Testing
Purity:> 85 % as determined by SDS-PAGE
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Phe 42
Molecule Mass:The recombinant human SUSD4/mFc is a disulfide-linked homodimer. The reduced monomer comprises 483 amino acids and has a predicted molecular mass of 53.8 kDa. The apparent molecular mass of the protein is approximately 67 in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human SUSD4 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human SUSD4 Protein SDS-PAGE
Human SUSD4 / Sushi domain-containing Protein 4 Protein (Fc Tag) SDS-PAGE
Other SUSD4 Recombinant Protein Products
SUSD4 / Sushi domain-containing protein 4 Background

SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical pathway of complement activation at the C3 convertase step. SUSD4 deficiency may cause autism or Fryns syndrome, both of which are genetic diseases with severe abnormal neurological development and/or functions.

Human SUSD4 / Sushi domain-containing protein 4 References
  • Kimura K. et al., 2006, Genome Res. 16 (1): 55-65.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Tu Z. et al., 2010, Am J Pathol. 176 (5): 2378-84.
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    Catalog: 13488-H05H-20
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.