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Human TCL1A Protein (His Tag)

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Human TCL1A Protein Product Information
Protein Construction:A DNA sequence encoding the human TCL1A (P56279) (Ala 2-Asp 114) was expressed, with a polyhistide tag at the N-terminus.
Expressed Host:E. coli
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human TCL1A Protein QC Testing
Purity:> 88 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human TCL1A consisting of 128 amino acids and has a calculated molecular mass of 15.2 kDa. It migrates as an 22 kDa band in SDS-PAGE under reducing conditions as predicted.
Formulation:Lyophilized from sterile PBS, pH 7.5
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human TCL1A Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Other TCL1A Recombinant Protein Products
TCL1A Background

T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8- precursor T cells and is extinguished at the CD4+CD8+ stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells and remains high in naive mantle zone B cells of peripheral lymphoid tissues. The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. It has been demonstrated that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas. All TCL1 isoforms bind to the Akt pleckstrin homology domain. Both in vitro and in vivo TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation. In vivo, TCL1 stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival. It has been shown that TCL1 is a novel Akt kinase coactivator, which promotes Akt-induced cell survival and proliferation.

Human TCL1A References
  • Jarmo Laine, et al. (2000) The Protooncogene TCL1 Is an Akt Kinase Coactivator. Molecular Cell. 6(2): 395-407.
  • Virgilio L, et al. (1994) Identification of the TCL1 gene involved in T-cell malignancies. PNAS December. 91(26): 12530-4.
  • Hoyer KK, et al. (2002) Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci U S A. 99(22): 14392-7.
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    Catalog: 13176-H07E-100
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