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Human IGJ / Immunoglobulin J chain Protein (His Tag)

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Human IGJ Protein Product Information
Synonym:IGCJ, JCH
Protein Construction:A DNA sequence encoding the mature form of human IGJ (NP_653247.1) (Gln 23-Asp 159) was fused with a polyhistidine tag at the C-terminus and a pelB singnal peptide at the N-terminus.
Expressed Host:E. coli
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human IGJ Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Gln 23
Molecule Mass:The recombinant human IGJ comprises 147 amino acids and has a predicted molecular mass of 17 kDa. It migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 8.0
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human IGJ Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human IGJ Protein SDS-PAGE
Human IGJ / Immunoglobulin J chain Protein (His Tag) SDS-PAGE
Other IGJ Recombinant Protein Products
IGJ Background

Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. Immunoglobulin J chain / IGJ also help to bind these immunoglobulins to secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but apparently also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.

Human IGJ References
  • Zikan, J. et al., 1985, Proc Natl Acad Sci USA. 82 (17): 5905-9.
  • Koshland, M.E. et al., 1985, Annu Rev Immunol. 3: 425-53.
  • Iwase,T. et al., 1993, Cell Struct Funct. 18 (5): 297-302.
  • Johansen, F.E. et al., 2000, Scand J Immunol. 52 (3): 240-8.
  • Lim, J.H. et al., 2006, J Immunol. 177 (8): 5420-9. 
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    Catalog: 13015-H08E-100
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.