|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CTSD ORF mammalian expression plasmid, C-GFPSpark tag||RG81328-ACG|
|Rat CTSD ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG81328-ACR|
|Rat CTSD ORF mammalian expression plasmid, C-Flag tag||RG81328-CF|
|Rat CTSD ORF mammalian expression plasmid, C-His tag||RG81328-CH|
|Rat CTSD ORF mammalian expression plasmid, C-Myc tag||RG81328-CM|
|Rat CTSD ORF mammalian expression plasmid, C-HA tag||RG81328-CY|
|Rat CTSD ORF mammalian expression plasmid, N-Flag tag||RG81328-NF|
|Rat CTSD ORF mammalian expression plasmid, N-His tag||RG81328-NH|
|Rat CTSD ORF mammalian expression plasmid, N-Myc tag||RG81328-NM|
|Rat CTSD ORF mammalian expression plasmid, N-HA tag||RG81328-NY|
|Rat CTSD Gene cDNA clone plasmid||RG81328-U|
|Rat CTSD natural ORF mammalian expression plasmid||RG81328-UT|
|Learn more about expression Vectors|
Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.