|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rabbit ERBB3 ORF mammalian expression plasmid, C-GFPSpark tag||TG65001-ACG|
|Rabbit ERBB3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||TG65001-ACR|
|Rabbit ERBB3 ORF mammalian expression plasmid, C-Flag tag||TG65001-CF|
|Rabbit ERBB3 ORF mammalian expression plasmid, C-His tag||TG65001-CH|
|Rabbit ERBB3 ORF mammalian expression plasmid, C-Myc tag||TG65001-CM|
|Rabbit ERBB3 ORF mammalian expression plasmid, C-HA tag||TG65001-CY|
|Rabbit ERBB3 Gene cDNA clone plasmid||TG65001-G|
|Rabbit ERBB3 ORF mammalian expression plasmid, N-Flag tag||TG65001-NF|
|Rabbit ERBB3 ORF mammalian expression plasmid, N-His tag||TG65001-NH|
|Rabbit ERBB3 ORF mammalian expression plasmid, N-Myc tag||TG65001-NM|
|Rabbit ERBB3 ORF mammalian expression plasmid, N-HA tag||TG65001-NY|
|Rabbit ERBB3 natural ORF mammalian expression plasmid||TG65001-UT|
|Learn more about expression Vectors|
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.