|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat CTSD ORF mammalian expression plasmid, C-GFPSpark tag||RG81328-ACG|
|Rat CTSD ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG81328-ACR|
|Rat CTSD ORF mammalian expression plasmid, C-Flag tag||RG81328-CF|
|Rat CTSD ORF mammalian expression plasmid, C-His tag||RG81328-CH|
|Rat CTSD ORF mammalian expression plasmid, C-Myc tag||RG81328-CM|
|Rat CTSD ORF mammalian expression plasmid, C-HA tag||RG81328-CY|
|Rat CTSD ORF mammalian expression plasmid, N-Flag tag||RG81328-NF|
|Rat CTSD ORF mammalian expression plasmid, N-His tag||RG81328-NH|
|Rat CTSD ORF mammalian expression plasmid, N-Myc tag||RG81328-NM|
|Rat CTSD ORF mammalian expression plasmid, N-HA tag||RG81328-NY|
|Rat CTSD Gene cDNA clone plasmid||RG81328-U|
|Rat CTSD natural ORF mammalian expression plasmid||RG81328-UT|
|Learn more about expression Vectors|
Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.