|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat KNG1 ORF mammalian expression plasmid, C-GFPSpark tag||RG81182-ACG|
|Rat KNG1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG81182-ACR|
|Rat KNG1 ORF mammalian expression plasmid, C-Flag tag||RG81182-CF|
|Rat KNG1 ORF mammalian expression plasmid, C-His tag||RG81182-CH|
|Rat KNG1 ORF mammalian expression plasmid, C-Myc tag||RG81182-CM|
|Rat KNG1 ORF mammalian expression plasmid, C-HA tag||RG81182-CY|
|Rat KNG1 ORF mammalian expression plasmid, N-Flag tag||RG81182-NF|
|Rat KNG1 ORF mammalian expression plasmid, N-His tag||RG81182-NH|
|Rat KNG1 ORF mammalian expression plasmid, N-Myc tag||RG81182-NM|
|Rat KNG1 ORF mammalian expression plasmid, N-HA tag||RG81182-NY|
|Rat KNG1 Gene cDNA clone plasmid||RG81182-U|
|Rat KNG1 natural ORF mammalian expression plasmid||RG81182-UT|
|Learn more about expression Vectors|
Mouse kininogen-1, also known as high molecular weight kininogen, williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1 and BDK, is a secreted protein which contains three cystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients, in fact, had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.