|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat PDPN ORF mammalian expression plasmid, C-GFPSpark tag||RG81154-ACG|
|Rat PDPN ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG81154-ACR|
|Rat PDPN ORF mammalian expression plasmid, C-Flag tag||RG81154-CF|
|Rat PDPN ORF mammalian expression plasmid, C-His tag||RG81154-CH|
|Rat PDPN ORF mammalian expression plasmid, C-Myc tag||RG81154-CM|
|Rat PDPN ORF mammalian expression plasmid, C-HA tag||RG81154-CY|
|Rat PDPN ORF mammalian expression plasmid, N-Flag tag||RG81154-NF|
|Rat PDPN ORF mammalian expression plasmid, N-His tag||RG81154-NH|
|Rat PDPN ORF mammalian expression plasmid, N-Myc tag||RG81154-NM|
|Rat PDPN ORF mammalian expression plasmid, N-HA tag||RG81154-NY|
|Rat PDPN Gene cDNA clone plasmid||RG81154-U|
|Rat PDPN natural ORF mammalian expression plasmid||RG81154-UT|
|Learn more about expression Vectors|
Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.