|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CFH ORF mammalian expression plasmid, C-GFPSpark tag||RG81017-ACG|
|Rat CFH ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG81017-ACR|
|Rat CFH ORF mammalian expression plasmid, N-GFPSpark tag||RG81017-ANG|
|Rat CFH ORF mammalian expression plasmid, N-OFPSpark / RFP tag||RG81017-ANR|
|Rat CFH ORF mammalian expression plasmid, C-Flag tag||RG81017-CF|
|Rat CFH ORF mammalian expression plasmid, C-His tag||RG81017-CH|
|Rat CFH ORF mammalian expression plasmid, C-Myc tag||RG81017-CM|
|Rat CFH ORF mammalian expression plasmid, C-HA tag||RG81017-CY|
|Rat CFH ORF mammalian expression plasmid, N-Flag tag||RG81017-NF|
|Rat CFH ORF mammalian expression plasmid, N-His tag||RG81017-NH|
|Rat CFH ORF mammalian expression plasmid, N-Myc tag||RG81017-NM|
|Rat CFH ORF mammalian expression plasmid, N-HA tag||RG81017-NY|
|Rat CFH Gene cDNA clone plasmid||RG81017-U|
|Rat CFH natural ORF mammalian expression plasmid||RG81017-UT|
|Learn more about expression Vectors|
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.