|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat SERPINC1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80654-ACG|
|Rat SERPINC1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80654-ACR|
|Rat SERPINC1 ORF mammalian expression plasmid, C-Flag tag||RG80654-CF|
|Rat SERPINC1 ORF mammalian expression plasmid, C-His tag||RG80654-CH|
|Rat SERPINC1 ORF mammalian expression plasmid, C-Myc tag||RG80654-CM|
|Rat SERPINC1 ORF mammalian expression plasmid, C-HA tag||RG80654-CY|
|Rat SERPINC1 ORF mammalian expression plasmid, N-Flag tag||RG80654-NF|
|Rat SERPINC1 ORF mammalian expression plasmid, N-His tag||RG80654-NH|
|Rat SERPINC1 ORF mammalian expression plasmid, N-Myc tag||RG80654-NM|
|Rat SERPINC1 ORF mammalian expression plasmid, N-HA tag||RG80654-NY|
|Rat SERPINC1 Gene cDNA clone plasmid||RG80654-U|
|Rat SERPINC1 natural ORF mammalian expression plasmid||RG80654-UT|
|Learn more about expression Vectors|
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization.