|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TTR ORF mammalian expression plasmid, C-GFPSpark tag||RG80728-ACG|
|Rat TTR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80728-ACR|
|Rat TTR ORF mammalian expression plasmid, C-Flag tag||RG80728-CF|
|Rat TTR ORF mammalian expression plasmid, C-His tag||RG80728-CH|
|Rat TTR ORF mammalian expression plasmid, C-Myc tag||RG80728-CM|
|Rat TTR ORF mammalian expression plasmid, C-HA tag||RG80728-CY|
|Rat TTR ORF mammalian expression plasmid, N-Flag tag||RG80728-NF|
|Rat TTR ORF mammalian expression plasmid, N-His tag||RG80728-NH|
|Rat TTR ORF mammalian expression plasmid, N-Myc tag||RG80728-NM|
|Rat TTR ORF mammalian expression plasmid, N-HA tag||RG80728-NY|
|Rat TTR Gene cDNA clone plasmid||RG80728-U|
|Rat TTR natural ORF mammalian expression plasmid||RG80728-UT|
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Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.