|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat MFGE8 ORF mammalian expression plasmid, C-GFPSpark tag||RG80522-ACG|
|Rat MFGE8 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80522-ACR|
|Rat MFGE8 ORF mammalian expression plasmid, C-Flag tag||RG80522-CF|
|Rat MFGE8 ORF mammalian expression plasmid, C-His tag||RG80522-CH|
|Rat MFGE8 ORF mammalian expression plasmid, C-Myc tag||RG80522-CM|
|Rat MFGE8 ORF mammalian expression plasmid, C-HA tag||RG80522-CY|
|Rat MFGE8 ORF mammalian expression plasmid, N-Flag tag||RG80522-NF|
|Rat MFGE8 ORF mammalian expression plasmid, N-His tag||RG80522-NH|
|Rat MFGE8 ORF mammalian expression plasmid, N-Myc tag||RG80522-NM|
|Rat MFGE8 ORF mammalian expression plasmid, N-HA tag||RG80522-NY|
|Rat MFGE8 Gene cDNA clone plasmid||RG80522-U|
|Rat MFGE8 natural ORF mammalian expression plasmid||RG80522-UT|
|Learn more about expression Vectors|
MFG-E8, also known as lactadherin and MFGE8, contains 1 EGF-like domain and 2 F5/8 type C domains. It also contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. It binds PS, which is exposed on the surface of apoptotic cells. MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. Overexpression of MFG-E8 can be found in several carcinomas. MFG-E8 has an opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. MFG-E8 plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. It promotes VEGF-dependent neovascularization and contributes to phagocytic removal of apoptotic cells in many tissues. It also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner.