|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TGM2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80519-ACG|
|Rat TGM2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80519-ACR|
|Rat TGM2 ORF mammalian expression plasmid, N-GFPSpark tag||RG80519-ANG|
|Rat TGM2 ORF mammalian expression plasmid, N-OFPSpark / RFP tag||RG80519-ANR|
|Rat TGM2 ORF mammalian expression plasmid, C-Flag tag||RG80519-CF|
|Rat TGM2 ORF mammalian expression plasmid, C-His tag||RG80519-CH|
|Rat TGM2 ORF mammalian expression plasmid, C-Myc tag||RG80519-CM|
|Rat TGM2 ORF mammalian expression plasmid, C-HA tag||RG80519-CY|
|Rat TGM2 ORF mammalian expression plasmid, N-Flag tag||RG80519-NF|
|Rat TGM2 ORF mammalian expression plasmid, N-His tag||RG80519-NH|
|Rat TGM2 ORF mammalian expression plasmid, N-Myc tag||RG80519-NM|
|Rat TGM2 ORF mammalian expression plasmid, N-HA tag||RG80519-NY|
|Rat TGM2 Gene cDNA clone plasmid||RG80519-U|
|Rat TGM2 natural ORF mammalian expression plasmid||RG80519-UT|
|Learn more about expression Vectors|
Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.