|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat SELP ORF mammalian expression plasmid, C-GFPSpark tag||RG80451-ACG|
|Rat SELP ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80451-ACR|
|Rat SELP ORF mammalian expression plasmid, C-Flag tag||RG80451-CF|
|Rat SELP ORF mammalian expression plasmid, C-His tag||RG80451-CH|
|Rat SELP ORF mammalian expression plasmid, C-Myc tag||RG80451-CM|
|Rat SELP ORF mammalian expression plasmid, C-HA tag||RG80451-CY|
|Rat SELP Gene cDNA clone plasmid||RG80451-G|
|Rat SELP ORF mammalian expression plasmid, N-Flag tag||RG80451-NF|
|Rat SELP ORF mammalian expression plasmid, N-His tag||RG80451-NH|
|Rat SELP ORF mammalian expression plasmid, N-Myc tag||RG80451-NM|
|Rat SELP ORF mammalian expression plasmid, N-HA tag||RG80451-NY|
|Rat SELP natural ORF mammalian expression plasmid||RG80451-UT|
|Learn more about expression Vectors|
P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interacton of activated endothelial cells or platelets with leukocytes.