|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CD276 ORF mammalian expression plasmid, C-GFPSpark tag||RG80380-ACG|
|Rat CD276 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80380-ACR|
|Rat CD276 ORF mammalian expression plasmid, C-Flag tag||RG80380-CF|
|Rat CD276 ORF mammalian expression plasmid, C-His tag||RG80380-CH|
|Rat CD276 ORF mammalian expression plasmid, C-Myc tag||RG80380-CM|
|Rat CD276 ORF mammalian expression plasmid, C-HA tag||RG80380-CY|
|Rat CD276 Gene cDNA clone plasmid||RG80380-G|
|Rat CD276 ORF mammalian expression plasmid, N-Flag tag||RG80380-NF|
|Rat CD276 ORF mammalian expression plasmid, N-His tag||RG80380-NH|
|Rat CD276 ORF mammalian expression plasmid, N-Myc tag||RG80380-NM|
|Rat CD276 ORF mammalian expression plasmid, N-HA tag||RG80380-NY|
|Rat CD276 natural ORF mammalian expression plasmid||RG80380-UT|
|Learn more about expression Vectors|
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.