|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat CD247 ORF mammalian expression plasmid, C-GFPSpark tag||RG80391-ACG|
|Rat CD247 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80391-ACR|
|Rat CD247 ORF mammalian expression plasmid, C-Flag tag||RG80391-CF|
|Rat CD247 ORF mammalian expression plasmid, C-His tag||RG80391-CH|
|Rat CD247 ORF mammalian expression plasmid, C-Myc tag||RG80391-CM|
|Rat CD247 ORF mammalian expression plasmid, C-HA tag||RG80391-CY|
|Rat CD247 Gene cDNA clone plasmid||RG80391-G|
|Rat CD247 ORF mammalian expression plasmid, N-Flag tag||RG80391-NF|
|Rat CD247 ORF mammalian expression plasmid, N-His tag||RG80391-NH|
|Rat CD247 ORF mammalian expression plasmid, N-Myc tag||RG80391-NM|
|Rat CD247 ORF mammalian expression plasmid, N-HA tag||RG80391-NY|
|Rat CD247 natural ORF mammalian expression plasmid||RG80391-UT|
|Learn more about expression Vectors|
CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.