|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat IL1A ORF mammalian expression plasmid, C-GFPSpark tag||RG80385-ACG|
|Rat IL1A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80385-ACR|
|Rat IL1A ORF mammalian expression plasmid, C-Flag tag||RG80385-CF|
|Rat IL1A ORF mammalian expression plasmid, C-His tag||RG80385-CH|
|Rat IL1A ORF mammalian expression plasmid, C-Myc tag||RG80385-CM|
|Rat IL1A ORF mammalian expression plasmid, C-HA tag||RG80385-CY|
|Rat IL1A Gene cDNA clone plasmid||RG80385-G|
|Rat IL1A ORF mammalian expression plasmid, N-Flag tag||RG80385-NF|
|Rat IL1A ORF mammalian expression plasmid, N-His tag||RG80385-NH|
|Rat IL1A ORF mammalian expression plasmid, N-Myc tag||RG80385-NM|
|Rat IL1A ORF mammalian expression plasmid, N-HA tag||RG80385-NY|
|Rat IL1A natural ORF mammalian expression plasmid||RG80385-UT|
|Learn more about expression Vectors|
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.