|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat SDC1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80344-ACG|
|Rat SDC1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80344-ACR|
|Rat SDC1 ORF mammalian expression plasmid, C-Flag tag||RG80344-CF|
|Rat SDC1 ORF mammalian expression plasmid, C-His tag||RG80344-CH|
|Rat SDC1 ORF mammalian expression plasmid, C-Myc tag||RG80344-CM|
|Rat SDC1 ORF mammalian expression plasmid, C-HA tag||RG80344-CY|
|Rat SDC1 Gene cDNA clone plasmid||RG80344-G|
|Rat SDC1 ORF mammalian expression plasmid, N-Flag tag||RG80344-NF|
|Rat SDC1 ORF mammalian expression plasmid, N-His tag||RG80344-NH|
|Rat SDC1 ORF mammalian expression plasmid, N-Myc tag||RG80344-NM|
|Rat SDC1 ORF mammalian expression plasmid, N-HA tag||RG80344-NY|
|Rat SDC1 natural ORF mammalian expression plasmid||RG80344-UT|
|Learn more about expression Vectors|
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.