|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat IL2RB ORF mammalian expression plasmid, C-GFPSpark tag||RG80340-ACG|
|Rat IL2RB ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80340-ACR|
|Rat IL2RB ORF mammalian expression plasmid, C-Flag tag||RG80340-CF|
|Rat IL2RB ORF mammalian expression plasmid, C-His tag||RG80340-CH|
|Rat IL2RB ORF mammalian expression plasmid, C-Myc tag||RG80340-CM|
|Rat IL2RB ORF mammalian expression plasmid, C-HA tag||RG80340-CY|
|Rat IL2RB Gene cDNA clone plasmid||RG80340-G|
|Rat IL2RB ORF mammalian expression plasmid, N-Flag tag||RG80340-NF|
|Rat IL2RB ORF mammalian expression plasmid, N-His tag||RG80340-NH|
|Rat IL2RB ORF mammalian expression plasmid, N-Myc tag||RG80340-NM|
|Rat IL2RB ORF mammalian expression plasmid, N-HA tag||RG80340-NY|
|Rat IL2RB natural ORF mammalian expression plasmid||RG80340-UT|
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Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.