|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CD96 ORF mammalian expression plasmid, C-GFPSpark tag||RG80338-ACG|
|Rat CD96 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80338-ACR|
|Rat CD96 ORF mammalian expression plasmid, C-Flag tag||RG80338-CF|
|Rat CD96 ORF mammalian expression plasmid, C-His tag||RG80338-CH|
|Rat CD96 ORF mammalian expression plasmid, C-Myc tag||RG80338-CM|
|Rat CD96 ORF mammalian expression plasmid, C-HA tag||RG80338-CY|
|Rat CD96 Gene cDNA clone plasmid||RG80338-G|
|Rat CD96 ORF mammalian expression plasmid, N-Flag tag||RG80338-NF|
|Rat CD96 ORF mammalian expression plasmid, N-His tag||RG80338-NH|
|Rat CD96 ORF mammalian expression plasmid, N-Myc tag||RG80338-NM|
|Rat CD96 ORF mammalian expression plasmid, N-HA tag||RG80338-NY|
|Rat CD96 natural ORF mammalian expression plasmid||RG80338-UT|
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The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.