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S100P Antibody, Rabbit PAb, Antigen Affinity Purified

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S100PAntibody Product Information
Immunogen:Recombinant Human S100P protein (Catalog#12635-HNAE)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human S100P (rh S100P; Catalog#12635-HNAE; P25815; Met 1-Lys 95). S100P specific IgG was purified by Human S100P affinity chromatography.
S100PAntibody Usage Guide
Specificity:Human S100P
Application:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100P. The detection limit for Human S100P is approximately 0.00975 ng/well.

IHC-P: 0.5-2 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Images
S100P Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human S100P in human placenta with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The image showing nucleus staining of trophoblastic cells.
S100P Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human S100P in human spleen with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Background

Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein which belongs to the S-100 family. S100P / S100E contains two EF-hand domains. S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S100P / S100E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S100P / S100E may directly confer resistance to chemotherapy. S100P / S100E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S100P / S100E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S100P / S100E may provide a novel approach for treatment of pancreatic cancer. S100P / S100E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.

References
  • Arumugam,T. et al., 2005, Clin Cancer Res. 11 (15): 5356-64.
  • Basu,G.D. et al., 2008, Int J Cancer. 123 (2): 330-9.
  • Rehbein,G. et al., 2008,Int J Mol Med. 22 (1): 69-77.
  • Heil,A. et al., 2011, J Biol Chem. 286 (9): 7227-38.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"