|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat PGC ORF mammalian expression plasmid, C-GFPSpark tag||RG80097-ACG|
|Rat PGC ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80097-ACR|
|Rat PGC ORF mammalian expression plasmid, C-Flag tag||RG80097-CF|
|Rat PGC ORF mammalian expression plasmid, C-His tag||RG80097-CH|
|Rat PGC ORF mammalian expression plasmid, C-Myc tag||RG80097-CM|
|Rat PGC ORF mammalian expression plasmid, C-HA tag||RG80097-CY|
|Rat PGC Gene cDNA clone plasmid||RG80097-G|
|Rat PGC ORF mammalian expression plasmid, N-Flag tag||RG80097-NF|
|Rat PGC ORF mammalian expression plasmid, N-His tag||RG80097-NH|
|Rat PGC ORF mammalian expression plasmid, N-Myc tag||RG80097-NM|
|Rat PGC ORF mammalian expression plasmid, N-HA tag||RG80097-NY|
|Rat PGC natural ORF mammalian expression plasmid||RG80097-UT|
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Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.