|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat CD69 ORF mammalian expression plasmid, C-GFPSpark tag||RG80209-ACG|
|Rat CD69 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80209-ACR|
|Rat CD69 ORF mammalian expression plasmid, C-Flag tag||RG80209-CF|
|Rat CD69 ORF mammalian expression plasmid, C-His tag||RG80209-CH|
|Rat CD69 ORF mammalian expression plasmid, C-Myc tag||RG80209-CM|
|Rat CD69 ORF mammalian expression plasmid, C-HA tag||RG80209-CY|
|Rat CD69 Gene cDNA clone plasmid||RG80209-G|
|Rat CD69 ORF mammalian expression plasmid, N-Flag tag||RG80209-NF|
|Rat CD69 ORF mammalian expression plasmid, N-His tag||RG80209-NH|
|Rat CD69 ORF mammalian expression plasmid, N-Myc tag||RG80209-NM|
|Rat CD69 ORF mammalian expression plasmid, N-HA tag||RG80209-NY|
|Rat CD69 natural ORF mammalian expression plasmid||RG80209-UT|
|Learn more about expression Vectors|
Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.