|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat EDA2R ORF mammalian expression plasmid, C-GFPSpark tag||RG80206-ACG|
|Rat EDA2R ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80206-ACR|
|Rat EDA2R ORF mammalian expression plasmid, C-Flag tag||RG80206-CF|
|Rat EDA2R ORF mammalian expression plasmid, C-His tag||RG80206-CH|
|Rat EDA2R ORF mammalian expression plasmid, C-Myc tag||RG80206-CM|
|Rat EDA2R ORF mammalian expression plasmid, C-HA tag||RG80206-CY|
|Rat EDA2R Gene cDNA clone plasmid||RG80206-G|
|Rat EDA2R ORF mammalian expression plasmid, N-Flag tag||RG80206-NF|
|Rat EDA2R ORF mammalian expression plasmid, N-His tag||RG80206-NH|
|Rat EDA2R ORF mammalian expression plasmid, N-Myc tag||RG80206-NM|
|Rat EDA2R ORF mammalian expression plasmid, N-HA tag||RG80206-NY|
|Rat EDA2R natural ORF mammalian expression plasmid||RG80206-UT|
|Learn more about expression Vectors|
Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).