|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat IL1R2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80196-ACG|
|Rat IL1R2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80196-ACR|
|Rat IL1R2 ORF mammalian expression plasmid, C-Flag tag||RG80196-CF|
|Rat IL1R2 ORF mammalian expression plasmid, C-His tag||RG80196-CH|
|Rat IL1R2 ORF mammalian expression plasmid, C-Myc tag||RG80196-CM|
|Rat IL1R2 ORF mammalian expression plasmid, C-HA tag||RG80196-CY|
|Rat IL1R2 Gene cDNA clone plasmid||RG80196-G|
|Rat IL1R2 ORF mammalian expression plasmid, N-Flag tag||RG80196-NF|
|Rat IL1R2 ORF mammalian expression plasmid, N-His tag||RG80196-NH|
|Rat IL1R2 ORF mammalian expression plasmid, N-Myc tag||RG80196-NM|
|Rat IL1R2 ORF mammalian expression plasmid, N-HA tag||RG80196-NY|
|Rat IL1R2 natural ORF mammalian expression plasmid||RG80196-UT|
|Learn more about expression Vectors|
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.