|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat IL12RB2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80185-ACG|
|Rat IL12RB2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80185-ACR|
|Rat IL12RB2 ORF mammalian expression plasmid, C-Flag tag||RG80185-CF|
|Rat IL12RB2 ORF mammalian expression plasmid, C-His tag||RG80185-CH|
|Rat IL12RB2 ORF mammalian expression plasmid, C-Myc tag||RG80185-CM|
|Rat IL12RB2 ORF mammalian expression plasmid, C-HA tag||RG80185-CY|
|Rat IL12RB2 Gene cDNA clone plasmid||RG80185-G|
|Rat IL12RB2 ORF mammalian expression plasmid, N-Flag tag||RG80185-NF|
|Rat IL12RB2 ORF mammalian expression plasmid, N-His tag||RG80185-NH|
|Rat IL12RB2 ORF mammalian expression plasmid, N-Myc tag||RG80185-NM|
|Rat IL12RB2 ORF mammalian expression plasmid, N-HA tag||RG80185-NY|
|Rat IL12RB2 natural ORF mammalian expression plasmid||RG80185-UT|
|Learn more about expression Vectors|
Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. IL12RB2 belongs to the type I cytokine receptor family. The coexpression of IL12RB2 and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of IL12RB2 is up-regulated by IFN gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of IL12RB2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. IL12RB2 promotes the proliferation of T-cells as well as NK cells. IL12RB2 induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.