|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat LCN2 / NGAL ORF mammalian expression plasmid, C-GFPSpark tag||RG80058-ACG|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80058-ACR|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, C-Flag tag||RG80058-CF|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, C-His tag||RG80058-CH|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, C-Myc tag||RG80058-CM|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, C-HA tag||RG80058-CY|
|Rat LCN2 / NGAL Gene cDNA clone plasmid||RG80058-M|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, N-Flag tag||RG80058-NF|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, N-His tag||RG80058-NH|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, N-Myc tag||RG80058-NM|
|Rat LCN2 / NGAL ORF mammalian expression plasmid, N-HA tag||RG80058-NY|
|Rat LCN2 / NGAL natural ORF mammalian expression plasmid||RG80058-UT|
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Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.