|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TNFRSF13C ORF mammalian expression plasmid, C-GFPSpark tag||RG80171-ACG|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80171-ACR|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-Flag tag||RG80171-CF|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-His tag||RG80171-CH|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-Myc tag||RG80171-CM|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-HA tag||RG80171-CY|
|Rat TNFRSF13C Gene cDNA clone plasmid||RG80171-G|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-Flag tag||RG80171-NF|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-His tag||RG80171-NH|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-Myc tag||RG80171-NM|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-HA tag||RG80171-NY|
|Rat TNFRSF13C natural ORF mammalian expression plasmid||RG80171-UT|
|Learn more about expression Vectors|
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.